发育异常

背景和目的：骨髓增生异常综合征（MDS）包括一组以血细胞发育异常和无效造血为特征的造血干细胞疾病，有很高的发生急性髓系白血病（AML）转化的危险性。

Background and objective : Myelodysplastic syndromes ( MDS ) is a heterogeneous group of hematopoietic stem cell disorders characterized by marrow cell dysplasia and ineffective hematopoiesis , with a high risk of transformation into acute myeloid leukemia ( AML ) .

重度胆囊发育异常与潜隐性胰腺胆汁反流有关

Severe dysplasia of the gallbladder associated with occult pancreatobiliary reflux

目的：分析前脑发育异常的CT表现。

Objective : To analyze the CT findings of prosencephalic anomaly .

CT对腰椎附件发育异常的诊断价值

Evaluation of CT diagnosis value in developmental anomaly of lumbar vertebrae appendage

结论CT是诊断腰椎附件发育异常的较好影像学方法。

Conclusion CT is an effective method in diagnosing the developmental anomaly of lumbar vertebrae appendage .

方法回顾分析本院16例经X线平片和CT检查确诊的腰椎发育异常的病例。

Methods The plain radiography and CT in 16 cases of developmental anomaly of lumbar vertebrae appendage were reviewed .

子宫发育异常的MRI诊断

MRI diagnosis of congenital uterine anomalies

结论婴幼儿脑瘫的颅脑CT检查有极高的价值，母体妊娠期胎儿脑发育异常可能是脑性瘫痪的主要原因。

The dysplasia of the infantile head in the period of pregnancy may be the first cause for cerebral palsy .

结论：CT检查可以清楚地把前脑发育异常的结构显示出来，具有很高的诊断价值。

Conclusion : CT scanning can show the abnormal structures of prosencephalic anomaly clearly , and is valuable in the diagnosis .

实验证实，结肠壁神经发育异常是HD的主要病理生理变化。

However , this experiment , has proved the pathophysiological changing of HD .

神经生理检查发现，他的脑电波轻度异常，核磁共振扫描（MRI）显示双侧脑室体后部和枕角周围白质和小脑发育异常。

Neurophysiology examination found that his brain wave was abnormal , MRI scans indicated that myelinated corpus callosum and cerebellum developed abnormally .

结论：Gs蛋白a亚单位突变是骨纤维发育异常的病因。

Conclusion : Gs α mutation is the etiology of fibrous dysplasia of bone .

结论CT是诊断先天性脑发育异常的首选方法，且对指导计划生育工作有重要意义。

Conclusion CT is the first choice and reliable means for detecting the congenital encephalodysplasia in the childhood and it has important significance for guiding the planning reproduction work .

6例性发育异常病残儿的SRY基因分析

Analysis of SRY Gene in 6 Cases With Sexual Abnormality

结论1、线粒体ATP生成减少与卵母细胞受精失败、受精卵未卵裂及胚胎发育异常可能有关。

Reduced ATP content may be related to failures in oocyte fertilization , zygote division and abnormal embryo development . 2 .

背景先天性心脏病（CongenitalHeartDisease，CHD）是胎儿时期心脏血管发育异常所致的心血管畸形，也是小儿最常见的心脏病。

Background Congenital heart disease ( CHD ) is due to metabolic disorders of heart and vessels in the development of embryos . It is the most common heart disease to children .

邻苯二甲酸二丁酯（DBP）致尿道下裂大鼠生殖与发育异常的实验研究

Study on Reproductive and Developmental Abnormalities in Hypospadiac Male Rats Induced by Maternal Exposure to Di-n-butyl Phthalate during Late Pregnancy

结论F~-可能通过抑制cyClinD1和PCNA的表达引起细胞增殖的抑制，导致牙胚发育异常。

Conclusion Fluoride may inhibit tooth-germ cell proliferation by restraining the expression of Cyclin D1 and PCNA , leading to the abnormal tooth development .

目的：了解Schmid型干骺软骨发育异常的临床特点。

Objective To evaluate the clinical features of metaphyseal chondrodysplasia Schmid type .

胎儿时期心脏血管发育异常而致的心脏和心脏大血管畸形称先天性心脏病（CHD）。

Abnormal development of heart and blood vessels in embryo with the result that defect of heart and cardiac vessels is called congenital heart disease ( CHD ) .

神经嵴细胞的发育异常可能参与了Cx43基因缺陷小鼠锥干部畸形的发病机制。

The abnormal distribution of cardiac neural crest cells is likely to contribute to the conotruncal malformations in Cx43-deficient mice .

结论①胎儿ASA的发生可能与妊娠早期FO处帘膜形成或继发隔的发育异常有关，因此与ASD密切相关；

Conclusions Fetal ASA may be associated with the formation of foramen oval 's membrane in early pregnancy or secondary growth abnormality of heart septum .

孤独症儿童发育异常评定高分组（DAS≥5分）与发育异常评定低分组（DAS<5）的ABC及CARS量表评定结果无显著性差异。

There was no significant difference between DAS high anomalies group ( DAS ≥ 5 ) and DAS low anomalies group ( DAS < 5 ) by CARS and ABC evaluation .

我们应用TCDD构建胎鼠生长发育异常的动物模型。

In this study , we built a model of abnormal growth fetal rats with TCDD .

CT均可发现附件发育异常，如：椎板裂6例，横突不对称1例，关节突异常肥大2例，关节突呈双突畸形2例，双侧小关节不对称5例。

Developmental anomaly of the appendage for all cases existed in CT images , such as vertebral lamina brisement in 6 cases , transverse process unsymmetry in 1 cases , hypertrophy , deformity or unsymmetry of intervertebral facet joints in 9 cases .

由于花药和胚珠中雌雄配子体发育异常的相似性，推测雌性不孕和雄性不育均是显性核不育基因Ms造成的结果，暗示着ms在雌性配子体减数分裂过程中均发挥着重要作用。

As the similarity of the abnormal development in anthers and ovules , suggesting dominant male sterile gene Ms causes the male and female sterility , it implied ms plays an important role in meiosis of the female gametophyte .

并且，研究发现，HPV阳性的发育异常的以及致瘤颈损伤以EZH2的高表达为特征。

Furthermore , we found that HPV-positive dysplastic and tumorigenic cervical lesions were characterized by high levels of EZH2 protein in vivo .

对性发育异常患者进行SRY基因检测，有利于了解该类患者的遗传学病因，为其诊断和治疗提供科学依据。

Checking the SRY gene for the patients with sexual abnormality , can help us to understand the genetic pathogeny and supply the scientific basis .

从GPI看教育发展过程中的性别差异性别畸形与性器官发育异常的超声诊断

Gender Differences in the Development of Education as Shown by GPI Ultrasonographic Study of the Intersex Problems and the Internal Genitalia Abnormalities

细胞松弛素B（CB）作为一种微丝解聚剂，可用于诱导贝类三倍体，但由于其毒副作用导致了受精卵死亡和发育异常。

Cytochalasin B ( CB ) is an inhibitor of microfilament . It is extensively used for polyploid induction in shellfish . However because of its toxicity CB treatment often results death and abnormal development of the fertilized eggs .