虫卵肉芽肿

研究结果深入阐明了血吸虫病免疫病理的分子机制，对寻找控制血吸虫虫卵肉芽肿病变的新途径，防止晚期血吸虫病的发生、发展具有重要的理论意义和应用价值。

These results have important theoretic and practical value for finding the new pathway to control eggs granuloma and preventing advanced schistosomiasis .

经吡喹酮治疗后色素沉积量明显减少、虫卵肉芽肿减小（P均<0·01）。

After chemotherapy with praziquantel , the level of pigment decreased considerably ( P < 0 ^ 01 ) and the size of granuloma shrinked obviously too ( P < 0 ^ 01 ) .

SEA致敏组和自然感染组各期虫卵肉芽肿内IgG抗体均呈阳性。

Immunohistochemical assay indicated IgG was positive in all granulomas of SEA sensitized group and cercariae infected group .

研究表明血吸虫虫卵肉芽肿病变与Th1／Th2免疫偏移密切相关，提示调控Th1／Th2免疫偏移是控制肉芽肿病变的有效途径。

Recent studies showed that regulating Th1 / Th2 immunodeviation is a effective method to control granulomatous formation .

结果疫苗免疫，尾蚴攻击后小鼠肝虫卵肉芽肿细胞内TNF－αmRNA表达显著加强。

Results The expression of TNF - α mRNA in egg granulomas in the liver of mice increased obviously by the immunization with the vaccine against challenge with Sj cercariae .

CD4～+CD25～+T细胞对日本血吸虫感染免疫应答及虫卵肉芽肿形成的影响

CD4 ~ + CD25 ~ + T Cells Can Down-regulate Immune Response and the Hepatic Egg Granuloma Formation of Mice in Infection with Schistosoma Japonicum

活化剂HYP协同425制剂的抗日本血吸虫虫卵肉芽肿病变免疫效应机理的研究

The immunoregulation mechanism of anti Schistosoma granuloma induced by activator Hyp coordinating " 425 " reagent

CpG诱导Th1型免疫应答及其对血吸虫肝虫卵肉芽肿病变调节作用的研究

Study of CpG Inducing a Th 1-type Immune Response and Regulating the Egg-granuloma in Liver Tissue of the Mice Infected with Schistosoma Japonicum

协同刺激分子B7对日本血吸虫感染小鼠肝虫卵肉芽肿病变的调控作用及其分子机制的研究

Study of B7 Costimulatory Molecule Regulating Liver Egg Granuloma Formation and Its Molecule Mechanism in Mice Infected with Schistosoma Japonicum

免疫组化结果显示，实验组肝虫卵肉芽肿细胞B7-1分子的表达增强、B7-2分子的表达减弱。

Immunohistochemistry showed enhanced expression of B7-1 and reduced expression of B7-2 on the hepatic granuloma of mAb-treated mice .

结论：吡喹酮治疗可使肝组织内SEA水平下降，从而抑制了虫卵肉芽肿的病变，但不能逆转已形成的虫卵肉芽肿病变。

CONCLUSION : Praziquantel treatment could lower the SEA level in the liver tissue , and thereby inhibit the egg granuloma formation , but it could not alter the antibody level , likewise , could not re - verse the egg granulomatous changes already formed .

VG染色显示实验组虫卵肉芽肿内胶原的平均光密度值明显小于对照组。

VG stain revealed that the average optical density of collagen in hepatic granulomas of experimental group was lower than that of control group .

实验结果显示，4种协同刺激分子均参与虫卵肉芽肿的形成，尤其是B7-2和CD40分子的作用更为显著。

The results show that the four co-stimulatory molecules anticipate the egg granuloma formation . Especially the effect of B7-2 and CD40 molecules are more significant .

目的研究日本血吸虫单克隆抗独特型抗体NP30对虫卵肉芽肿的影响。

Objective To study the immunoregulative effect of the monoclonal anti-idiotypic antibody NP30 of Schistosoma japonicum on egg granulomas .

结果虫卵肉芽肿细胞均表达Bax、Fas、FasL和c-Fos蛋白，其中实验组Bax和FasL蛋白表达均高于对照组（P<0.05）；

Results The expressions of Bax , Fas , FasL and c-Fos were positive in granuloma cells of both groups . The expressions of Bax and FasL in experimental group were higher than those in control group ( P < 0.05 ) .

本研究表明CpG作为一个新型的免疫调节剂及其作为潜在的疫苗佐剂具有重要的理论和应用价值，研究结果为探索控制日本血吸虫虫卵肉芽肿病变的新途径提供了实验依据。

Together with the results , CpG as a new kind of immune mediator and a potential vaccine adjuvant has an important theoretic and practical value for finding a novel approach to control egg-granuloma and prevent advanced schistosomiasis .

型胶原表达在肝窦壁、中央静脉壁、Disse腔、虫卵肉芽肿内及其周围，呈弥漫状分布，伴有门管区胶原纤维隔形成和窦壁完整的基膜形成；

Type ⅰ, ⅲ collagens were mainly expressed in walls of liver sinus and central veins , Disse cavity , and around granuloma of worm ova .

对日本血吸虫虫卵肉芽肿形成的人工诱发特异性免疫调节

Artificial induction of specific immune modulation on Schistosoma japonicum egg granulomas

小鼠日本血吸虫肝虫卵肉芽肿模型的建立

Establishment of experimental model of hepatic Schistosoma japonicum egg granulomas in mice

吡喹酮对感染血吸虫小鼠血清羟脯氨酸及肝脏虫卵肉芽肿作用的探讨

Effects of praziquantel on serum hydroxyproline and hepatic egg granuloma in schistosome infected mice

曼氏血吸虫感染鼠肝脏虫卵肉芽肿反应及胶原含量定量测定

Quantitative detection on granuloma and collagen contents in livers of mice infected with Schistosoma mansoni

干扰素在体外对模拟的曼氏血吸虫虫卵肉芽肿的抑制作用

In vitro inhibitory effect of interferon on simulated granuloma formation by eggs of Schistosoma mansoni

日本血吸虫虫卵肉芽肿与肝纤维化免疫病理及调节研究初步报告

Studies on immunopathology and immunological regulation of egg granuloma and liver fibrosis in Schistosoma japonicum infections

细胞信号转导抑制剂介导Th1/Th2免疫偏移对血吸虫虫卵肉芽肿的影响

Effect of Inhibitors of Cell Signal Transduction on Egg Granuloma Formation in Mice Infected with Schistosoma japonicum

并且检测感染小鼠虫卵肉芽肿体积。

Meanwhile , the size of granuloma induced by eggs of worms in the infected mice was measured .

日本血吸虫虫卵肉芽肿内抗原和抗体的动态

The dynamics of antigen and antibody in Schistosoma japonicum egg granuloma and its relationship with the granuloma response

雷公藤对急性期虫卵肉芽肿可有促进发展作用，而对慢性期虫卵肉芽肿则有抑制作用。

The effects of Triterygium wilfordii on the egg granuloma and eosinophils presented a process from immunoenhancement to immunosuppression .

转基因小鼠肝虫卵肉芽肿体积显著大于同期对照组的肉芽肿，增大率分别为24.48%和26.37%（P<0.01）。

The rate of egg granuloma enlargement was 24.48 % and 26.37 % at week 6 and 8 respectively .

血吸虫病主要死于肝虫卵肉芽肿以及继发性的肝纤维化。

The primary cause of death in schistosomiasis is the formation of liver egg granulomas and secondary hepatic fibrosis .

但抗性株治疗组和未治疗组虫卵肉芽肿均由大量炎性浸润细胞和少量间质成纤维细胞组成，两组虫卵肉芽肿的面积间差异无显著性。

There were no differences between untreated and treated groups with respect to the size of egg-granulomas in the livers .