免疫球蛋白基因

目的建立成熟的体外扩增多样性人免疫球蛋白基因的实验方法。

Objective To establish a usable method for the amplification of human diversified immunoglobulin genes .

结果利用不同引物进行的PCR反应均成功扩增出相应的免疫球蛋白基因，经鉴定所获得的基因产物具有良好的多样性，在天然抗角蛋白自身抗体研究和抗体库的构建中得到初步应用。

Results All the intent immunoglobulin genes were successfully amplified and the obtained products were identified correct and with very good diversity .

从淋巴瘤患者外周血获得免疫球蛋白基因IgHV片段，将其与IL-2基因连接后形成的融合基因克隆到真核表达载体中。

The IgHV gene fragments were obtained from the peripheral blood of patients with lymphoma , and were cloned into eukaryotic expression vector .

免疫球蛋白基因超家族（IgSF）包括很多成员，它们都参予免疫应答及免疫调节。

Abstract Immunoglobulin gene superfamily ( IgSF ) include many members which take part in immune response and immunoregulation .

ALCAM主要表达在白细胞和胸腺上皮细胞，属于免疫球蛋白基因超家族的成员，是淋巴细胞抗原CD6的配基。

ALCAM belongs to immunoglobulin gene superfamily . It is mainly expressed on leucocyte and thymic epithelial cell and is the ligand of CD6 lymphocyte antigen .

下调的基因主要是免疫球蛋白基因。

The immunoglobulin genes were down - regulated . protein binding ;

从外周血单个核细胞扩增多样性人免疫球蛋白基因的研究

Amplification of human diversified immunoglobulin genes from peripheral blood mononuclear cells

鱼类免疫球蛋白基因结构及抗体多样性的遗传机制

Gene Structure and Genetic Diversity of Immunoglobulins in Fish

急性淋巴细胞白血病恶性克隆的免疫球蛋白基因特征分析

Characteristics of malignant clone from acute lymphocytic leukemia

转染细胞毒性T淋巴细胞相关抗原4免疫球蛋白基因的同供体大鼠树突状细胞对胰岛移植物存活的影响

Effect cytotoxic T lymphocyte associated antigen-4 immunoglobulin gene transfer to the same donor dendritic cells on rat pancreatic islet allografts

序列分析显示，所获抗体克隆的可变区基因分别属于免疫球蛋白基因家族的不同亚群。

DNA sequence analyses indicated that the variable region gene of the obtained clones belonged to the different subgroups of immunoglobulin gene family .

大容量人免疫球蛋白G基因文库的构建及初步应用

Construction and preliminary use of a large human IgG gene library

这种B细胞克隆的免疫球蛋白重排基因在肿瘤组织中有丰富表达，所产生的免疫球蛋白可能直接与皮肤中的抗原发生作用，引起皮肤黏膜的免疫损伤。

The B - cell clone is expressed and maybe produces functional antibody initiating the mucocutaneous immune injury .

免疫球蛋白kappa基因重排在B细胞增殖性疾病中的检测及其应用

A Study of Immunoglobulin Kappa Light Chain Gene Rearrangement in the B Cell Lymphoproliferative Diseases and Its Clinical Value

FL中免疫球蛋白IgH基因重排检出率比其他小B细胞淋巴瘤低。

Clonal IgH rearrangements of FL were detected lower compare to other small B-cell lymphoma .

多聚免疫球蛋白受体基因的多态性与鼻咽癌易感性的关系

Correlation of Polymeric Immunoglobulin Receptor Gene Polymorphisms to Susceptibility of Nasopharyngeal Carcinoma

本文对鱼类免疫球蛋白的基因结构以及抗体多样性产生的遗传机制作一综述。

The current knowledge concerning the structure of fish immunoglobulin ( Ig ) genes and the genetic mechanisms in generating fish antibody diversities is reviewed .

石蜡包埋B细胞性恶性淋巴瘤组织克隆性免疫球蛋白重链基因重排检测研究

Study on Detection of Clonal Immunoglobulin Heavy Chain Gene Rearrangement in Paraffin-embedded Tissues from B-cell Lymphomas

B细胞淋巴瘤免疫球蛋白重链基因重排的检测

The Detection of Rearrangement of Immunoglobulin Heavy Chain ( IgH ) Gene in B Cell Lymphoma

克隆性免疫球蛋白重链基因重排检测可以作为诊断恶性B细胞性非霍奇金淋巴瘤的有效分子标志。

Clonal immunoglobulin heavy chain gene rearrangement can be used as a effective diagnostic molecular marker for B-NHL .

免疫球蛋白重链基因重排及bcl-2/JH融合基因检测眼眶淋巴细胞增生性疾病

The clinical value of rearrangement of IgH gene and bcl-2 / J_H fuse gene in the diagnosis of orbital lymphoproliferative disorders

NK细胞表面免疫球蛋白受体KIR基因的分析

Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese

目的分析慢性B淋巴细胞白血病患者外周血单个核细胞免疫球蛋白Fab段基因。

Objective Sequences analysis of Ig variable regions from the peripheral blood mononuclear cells ( PBMC ) of patients with chronic B lymphocytic leukemia .

人类杀伤细胞免疫球蛋白样受体基因PCR-SSP分型方法的建立及其应用

The establishment of PCR-SSP method for killer cell immunoglobulin-like receptor gene family and its application

牛免疫球蛋白重链基因中JH，Eμ片段敲除的研究和JH，Cμ基因的分析

The Research of Gene Targeting of the Bovine Immunoglobulin Heavy Chain JH , E μ Locus and Analysis of JH , C μ Genes in the Bovine Germline Gene

UCD一般免疫球蛋白重链基因重排阴性，MCD基因重排部分为阳性。

The immunoglobulin gene rearrangement analysis in UCD is negative while parts of MCD cases are positive .

将鼠源性单抗杂交瘤细胞中已克隆到的重、轻链可变区（VH、Vk）基因分别与人免疫球蛋白恒定区基因Cr3、Ck相拼接，构建鼠人嵌合抗体基因。

The genes encoding the heavy and light chain variable region ( VH and Vk ) were combined to the human Cr3 and Ck genes respectively to construct the murine-human chimeric antibody genes .

不同胎龄新生儿免疫球蛋白重链基因CDR3序列特征

Feature of immunoglobulin heavy chain complementarity determining region 3 gene in neonates with different gestational age

结论：成功克隆抗跨膜TNF-？单克隆抗体C1轻链及重链可变区基因，经序列分析证明为一对功能性免疫球蛋白可变区基因。

Conclusion : We have successfully cloned light chain and heavy chain variable region gene of anti - TM-TNF - α monoclonal antibody C1 , which is confirmed to be a new pair of functional rearranged variable region gene by immunoglobulin sequence analysis .

结果：VH基因序列全长369个碱基对，编码123个氨基酸，通过国际联机检索及Kabat库扫描证实，该VH基因符合小鼠免疫球蛋白可变区基因特征，同源性最高达87%。

Results : The VH gene contained 369 base pairs encoding 123 amine acid resides . Analysis of the nucleotide sequence of the light chain variable region revealed that the VH sequence was 87 % identical to the sequence present in mouse Ig VH region .